Impact of Vitamin D3 on Sleep Disturbance and Covid- 19 Infection

Introduction: Mounting research suggests that vitamin D plays a crucial role in regulating sleep. In particular, insufficient levels of vitamin D have been linked to an increased likelihood of sleep disorders and are correlated with difficulties falling asleep, reduced total sleep time, and waking up during the night in both children and adults.

Aim of study: To evaluate the association if vitamin D with sleep disturbance and previous Covid 19 infection and vaccination

Patients and methods: This retrospective study of include 51 individuals sent for vitamin D3 level and evaluated for sleep disturbance and history of previous Covid 19 infection and Covid vaccination .the individuals with vaccination divided into two groups with single one and with two doses.

Results and discussion: In this study no significant between male and female regarding sleep disturbance and previous covid infection and vaccination in this study no significant difference regarding the age between male and females P value 0.511 and no significant difference in vitamin D3 level between male and female P value 0.363 as seen in table 2 slightly lower in female this go with many studies that show such difference In this study there is no significant difference between sleep disturbance and vitamin D level  Increasingly, scientific studies have shown that vitamin D plays a significant part in regulating sleep patterns. Specifically, a lack of vitamin D, known as vitamin D deficiency (VDD), can raise the likelihood of developing sleep disorders and is linked to problems with falling asleep, shorter periods of sleep, and waking up during the night in both children and adults. While the precise mechanisms through which vitamin D influences sleep are not yet fully understood, possible explanations include the presence of vitamin D receptors on key areas of the brainstem that act as pacemaker cells in regulating sleep, as well as the potential role of vitamin D in modulating the hormone melatonin, which is closely associated with sleep In this study, there is no significant difference between the previous history of Covid 19 infection and the status of vitamin D The first study (doi:10.1136/bmj-2022-071230) was conducted in the United Kingdom between May and October 2021.11 Jolliffe and colleagues randomized 3100 participants to a vitamin D test and either 3200 IU/day or 800 IU/day of vitamin D3 for six months if their blood 25-hydroxyvitamin D concentrations were <75 nmol/L. A further 3100 controls received no test and no supplementation. The authors found that neither of the vitamin D doses had any effect on the incidence of covid-19. This trial had several strengths: a high prevalence (64.6%) of participants with inadequate 25-hydroxyvitamin D levels (<50 nmol/L), good adherence to the protocol, and a rigorous endpoint with polymerase chain reaction confirmed covid-19.in this study no significant difference between  vitamin D level and state of vaccination against covid 19 New research indicates that having insufficient levels of vitamin D is an independent risk factor for more severe illness, regardless of a person's age or weight. While it is possible that low vitamin D levels may increase the likelihood of contracting COVID-19, this hypothesis has less of a scientific basis. A systematic review and meta-analysis study found that evidence supporting a cause-and-effect relationship between vitamin D status and various COVID-19-related health outcomes is currently uncertain. In this study no correlation between sleep disturbance and previous covid 19 infections The most recent meta-analysis, a review of all the currently available scientific literature, estimates that 52% of people who contract COVID suffer from sleep disturbances during the infection .The most common type of sleep disturbance reported is insomnia