Evaluation of some coagulation factors in lymphoid malignant patients on chemotherapeutic agents in Benin City, edo state.
Abstract
Background and objective: The association of coagulation factors in lymphoid malignancy, angiogenesis and metastasis is of great value. The metastasized
lymphoid malignancies that defer surgical operation or radiation can only be managed by Chemotherapeutic agents. There-fore, the aim of this study was to evaluate some coagulation factors changes such as factor VIII and factor VII level in lymphoid malignant patients on chemotherapeutic agents in order to determine their clinical relevance.
Materials and Method: It was a prospective study carried out in tertiary hospital in Benin City, Edo State. Sixty (60) patients, compris-ing of twenty (20) lymphoid malignant patients on Chemotherapeutic agents, twenty (20) novel lymphoid malignant patients and twenty (20) controls participated in the study. Using aseptic precaution, 4.5mls of venous blood were collected into a plastic tube containing 0.5ml of aqueous tri-sodium citrate and was separated by centrifugation at 4000rpm for 15 minutes to obtain citrated plasma for coagulation fac-tors analysis. One-stage method was used for quantitative measurement ofcoagulation factor VII and factor VIII.
Results: The results indicated that there was very significant decrease of coagulation factors (p<0.000) of novel lymphoid malignant pa-tients and lymphoid malignant patients on chemotherapy compared with control. Furthermore, comparing lymphoid malignant patients on chemotherapy with novel lymphoid malignant patients, there were also significant declines (p<0.04, p<0.012 ).
Conclusion: the results revealed that lymphoid malignancy is associated with coagulation disorder and chemotherapeutic agents could had activated the coagulation system through the release of procoagulant fibrinolytic substances by tumor cells, or through endothelial damage or the stimulation of tissue factor
production by host cells. For effective management of the lymphoid malignant patients, there should be a routine screening for all the specific single coagulation
factors assay before and after chemotherapy administration and anticoagulant therapy should be incorporated in the treatment regime
How to Cite
Onuoha, Chinedu Emmanuel*, Osime, Evarista Odaburhine, Omoti, Caroline Edijana, Eledo, Onyema Benjamin, Hallie, Ezekiel Fayiah, Edeh, Kelechi Favour, Diepreye, Aaron Tracy . (2021). Evaluation of some coagulation factors in lymphoid malignant patients on chemotherapeutic agents in Benin City, edo state.. Advance Research Journal of Medical and Clinical Science , Vol. 7 No. 11 (2021): Advance Research Journal of medical and clinical science , 713-716 .
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